ChIP-seq中peak的形状

2016-07-11

ChIP-seq数据分析时，可产生各种各样的Peak。四个例子:

CTCF: 			    sharp binding sites
RNA polymerase II:	a mixture of shapes
H3K36me3: 		    medium size broad peaks
H3K27me3.		     large domains

本质上有三种:
a. puncate regions covering a few hundred base pairs or less
b. localized but broader reigons of up to a few kilobases
c. broad regions up to several hundred kilobases, 大部分有用的组蛋白标记和染色体区域位置.